Benincasa hispida Extract Prevents Ovariectomy-Induced Osteoporosis in Female ICR Mice

With the increase in bone metabolic diseases owing to aging of global population, interest functional food ingredients for improving health is increasing. This study aimed determine anti-osteoporosis effect Benincasa hispida extract (BHE, HR1901-W) and 2-furoic acid ovariectomy (OVX)-induced osteoporosis female ICR mice. Thirty-five mice underwent OVX or sham operation were randomized into seven groups five animals as follows: normal, sham, OVX, with genistein (10 mg/kg), (20 LBHE (100 HBHE (200 mg/kg). After an 8-week treatment period, femur blood samples collected from Bone density formation markers significantly recovered supplementation compared those group. In addition, resorption increased mice, whereas they decreased + groups. suggests that BHE prevents promotes These findings indicate could be used a promising natural means prevent OVX-induced diseases.